Electroporation-based therapies (EPTs) consist in applying high voltage short pulses to cells in order to create defects in the plasma membrane. They provide interesting alternatives to standard ablative techniques, for instance for deep seated badly located tumors. However their use is still limited due to a lack of knowledge of tissue electroporation. The goal of the associate team is to focus on the multiscale numerical modeling of spheroid electroporation, in order to provide new insights in electroporation at the mesoscopic scales (spheroids provide interesting tumor-like biological models). Benefiting from the expertise of F. Gibou’s team in HPC for multiphysics, and the expertise of the team MONC in tumor growth and cell electroporation modeling, the goal of the associate team Num4SEP is to obtain accurate and efficient numerical tools for the quantitative evaluation of the EPTs at the mesoscopic scale.
Num4SEP is lead by C. Poignard, research scientist at Inria and F. Gibou, Prof. at UCSB.
Floriane Gidel, postdoctoral fellow of the associate team has been awarded "French Young Talent 2019 - L'Oréal-UNESCO for Women in Science" for her project on numerical electroporation. Congratulations to her!See her interview here.
F. Gibou and P. Mistani have been interviwed by the TEXAS ADVANCED COMPUTING CENTER!See the article here.